منابع مشابه
Studies on Fluorinated Pyrimidines
We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by Duschinsky et al. (5), and on the initial clinical trials of 5fluorouracil with patients with far advanced solid tumors (6). The metabolism of 5-fluorouracil and 5-fluororotic acid has been studied, data on excretion and tissue distribution in mice and man have been repor...
متن کاملStudies on fluorinated pyrimidines. II. Effects on transplanted tumors.
In 1954, Rutman, Cantarow, and Paschkis re ported an increased utilization of labeled uracil in primary induced rat hepatoma as compared with normal liver (22); similar observations with the transplanted Flexner-Jobling carcinoma, together with some studies on the mechanism of this effect, were reported from this laboratory (15). This in creased utilization of uracil for nucleic acid bio synthe...
متن کاملStudies on fluorinated pyrimidines. VIII. Further biochemical and metabolic investigations.
We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by Duschinsky et al. (5), and on the initial clinical trials of 5fluorouracil with patients with far advanced solid tumors (6). The metabolism of 5-fluorouracil and 5-fluororotic acid has been studied, data on excretion and tissue distribution in mice and man have been repor...
متن کاملStudies on fluorinated pyrimidines. XI. In vitro studies on tumor resistance.
Various biochemical studies have been carried out in vitro with Ehrlich ascites car cinoma cells susceptible and resistant to fluorinated pyrimidines. There is no major difference between the two cell lines with respect to the utilization of formate or thy midine for DNA thymine biosynthesis, nor the incorporation of uracil or orotic acid into RNA uracil. The incorporation of formate-C'4 into D...
متن کاملComparative studies of fluorinated pyrimidines with various cell lines.
pound (1 7) with useful clinical activity ( 16), a wide variety of pyrimidines and nucleoside analogs of various types have been synthesized and their biologic and biochemical activities de scribed. This laboratory has been engaged in the synthesis and study of a number of other fluorinated pyrimidines (cf 14), among which the most interesting are FUR, FUDR (14), and F3TDR (18). Recently we hav...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)98169-x